Cristina Yang leaves Seattle. Isaiah Washington, who played Dr. Preston Burke, will be back at some point but that doesn't seem to be coming up quite yet. The official synopsis for Change of Heart at TV Guide shares that there will be some bad news coming from Jackson in episode 10x21. Derek's sister Amelia hits town for a surprise visit and Richard will fly out to Boston to spend some time with Catherine. Bailey makes a big decision as a result of her frustration with her research. Another Spoiler TV sneak peek shows Arizona and Alex on a plane together.
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